Intoxicaciones agudas atendidas en un servicio de urgencias. De la prepandemia a la nueva normalidad / Acute poisoning among patients attended to in an emergency department: From the pre-pandemic period to the new normality

Fundamentos La pandemia por COVID-19 ha provocado cambios globales que afectan a la vida diaria de la población mundial, con un impacto directo sobre la salud física y mental de los individuos, así como en sus hábitos sociales y recreativos. Métodos Análisis retrospectivo de aspectos demográficos y clínicos de los pacientes atendidos por intoxicaciones agudas en un servicio de urgencias hospitalario durante 3 períodos distintos: prepandemia (2019), tras el confinamiento domiciliario (2020) y en el período pospandémico (2021), analizando en cada uno los meses de junio y julio. Resultados Se incluyeron 1.182 intoxicaciones agudas. En relación con la etapa prepandémica, el número de intoxicados disminuyó durante el confinamiento (2019: 1,9 vs. 2020: 1,5%; p<0,01), incrementándose la ratio varón/mujer (2,0 vs. 1,4; p=0,02) y la edad media (2019: 31,4 vs. 2020: 41,3; p<0,001), tendencia que se mantuvo en el año 2021 (38,3). La intoxicación con motivación suicida también aumentó en dicho período (2019: 8,71 vs. 2020: 21,0%; p<0,01), mientras que las lúdicas decrecieron (2019: 76,1 vs. 2020: 62,0%; p<0,01), con un aumento no significativo en el último año 2021 (69,0%; p=0,07). Conclusiones La pandemia por COVID-19 ha generado cambios clínicos y epidemiológicos en las intoxicaciones agudas atendidas en un servicio de urgencias hospitalario durante las distintas fases de la pandemia (AU)

Background The COVID-19 pandemic has caused global changes that affect the daily life of the world's population, with a direct impact on individuals’ physical and mental health as well as on their social and recreational habits. Methods This study aimed to retrospectively analyze the demographic and clinical characteristics of patients attended to for acute poisoning in a hospital emergency department (ED) at three different periods of time: pre-pandemic (2019), after strict lockdown of the population in Spain (2020), and post-pandemic (2021). We analyzed 2 months (June and July) in each period. Results A total of 1,182 cases of acute poisoning were included. Compared to the pre-pandemic period, during lockdown, the number of patients with acute poisoning decreased (2019: 1.9% vs. 2020: 1.5%; p<.01); the ratio of men to women increased (2.0 vs. 1.4; p=.02); and the mean age of patients increased (2019: 31.4 vs. 2020: 41.3; p<.001), a trend which continued in 2021 (38.3). Poisoning with suicidal intention also increased during the pandemic (2019: 8.71% vs. 2020: 21.0%; p<.01) whereas poisonings with a recreational intention declined (2019: 76.1% vs. 2020: 62.0%; p<.01) with a non-significant increase in 2021 (69.0%, p=.07). Conclusion The COVID-19 pandemic generated clinical and epidemiological changes in the acute poisonings attended to in a hospital emergency department during the various phases of the pandemic (AU)

Acute poisoning among patients attended to in an emergency department: from the pre-pandemic period to the new normality.

BACKGROUND: The COVID-19 pandemic has caused global changes that affect the daily life of the world's population, with a direct impact on individuals' physical and mental health as well as on their social and recreational habits. METHODS: This study aimed to retrospectively analyze the demographic and clinical characteristics of patients attended to for acute poisoning in a hospital emergency department (ED) at three different periods of time: pre-pandemic (2019), after strict lockdown of the population in Spain (2020), and post-pandemic (2021). We analyzed 2 months (June and July) in each period. RESULTS: A total of 1,182 cases of acute poisoning were included. Compared to the pre-pandemic period, during lockdown, the number of patients with acute poisoning decreased (2019: 1.9% vs. 2020: 1.5%; p < 0.01); the ratio of men to women increased (2.0 vs. 1.4; p = 0.02); and the mean age of patients increased (2019: 31.4 vs. 2020: 41.3; p < 0.001), a trend which continued in 2021 (38.3). Poisoning with suicidal intention also increased during the pandemic (2019: 8.71% vs. 2020: 21.0%; p < 0.01) whereas poisonings with a recreational intention declined (2019: 76.1% vs. 2020: 62.0%; p < 0.01) with a non-significant increase in 2021 (69.0%, p = 0.07). CONCLUSION: The COVID-19 pandemic generated clinical and epidemiological changes in the acute poisonings attended to in a hospital emergency department during the various phases of the pandemic.

[Acute poisoning among patients attended to in an emergency department: From the pre-pandemic period to the new normality]. / Intoxicaciones agudas atendidas en un servicio de urgencias. De la prepandemia a la nueva normalidad.

Background: The COVID-19 pandemic has caused global changes that affect the daily life of the world's population, with a direct impact on individuals' physical and mental health as well as on their social and recreational habits. Methods: This study aimed to retrospectively analyze the demographic and clinical characteristics of patients attended to for acute poisoning in a hospital emergency department (ED) at three different periods of time: pre-pandemic (2019), after strict lockdown of the population in Spain (2020), and post-pandemic (2021). We analyzed 2 months (June and July) in each period. Results: A total of 1,182 cases of acute poisoning were included. Compared to the pre-pandemic period, during lockdown, the number of patients with acute poisoning decreased (2019: 1.9% vs. 2020: 1.5%; p<.01); the ratio of men to women increased (2.0 vs. 1.4; p=.02); and the mean age of patients increased (2019: 31.4 vs. 2020: 41.3; p<.001), a trend which continued in 2021 (38.3). Poisoning with suicidal intention also increased during the pandemic (2019: 8.71% vs. 2020: 21.0%; p<.01) whereas poisonings with a recreational intention declined (2019: 76.1% vs. 2020: 62.0%; p<.01) with a non-significant increase in 2021 (69.0%, p=.07). Conclusion: The COVID-19 pandemic generated clinical and epidemiological changes in the acute poisonings attended to in a hospital emergency department during the various phases of the pandemic.

Intoxicaciones en la tercera edad / Poisoning among the elderly

Objetivos Las intoxicaciones siguen siendo un problema de salud pública importante. En el presente estudio evaluamos la epidemiología de las intoxicaciones en la tercera edad. Métodos Estudio de cohorte retrospectivo realizado entre 2011 y 2019 en un hospital universitario. Analizamos variables demográficas, tipo de tóxico involucrado, naturaleza suicida o accidental de la intoxicación y la probabilidad de ingreso o muerte en el hospital. Resultados Un total de 880 (6,1%) de las 14.300 intoxicaciones atendidas en el mismo período sucedieron en mayores de 65 años. El grupo más numeroso fueron individuos entre 65-69 años (39%), seguidos por el grupo de 70-75 años (20%), siendo varones el 57%. En el 88% de los casos participó un único tóxico, por orden de frecuencia alcohol (51,6%), fármacos (29,5%) y productos domésticos o industriales (12,8%). Las intoxicaciones por alcohol predominaron en hombres hasta los 75 años y por encima de esta edad predominó la intoxicación farmacológica o suicida, principalmente en mujeres. Ingresaron un total de 145 (16%) sujetos, siendo los fármacos más frecuentemente implicados digoxina y benzodiacepinas. La probabilidad de ingreso se asoció con la intoxicación por metformina, digoxina, litio o la edad del paciente (OR por año = 1,03; IC 95%: 1,0-1,06). Fallecieron 19 pacientes (2,16%), principalmente por ingestas cáusticas suicidas (OR = 5,7: IC 95%: 1,4-23,6) o por fármacos, relacionados directamente con la metformina (OR = 10,1; IC 95%: 2,4-42,4). Conclusiones La prevalencia de intoxicaciones en la tercera edad no es despreciable, y los médicos deben sospecharlas ante situaciones clínicas complejas (AU)

Objectives Poisonings continue to be an important public health problem. Herein, we analyzed the epidemiology of poisonings in elderly individuals. Methods Retrospective cohort study conducted between 2011 and 2019 in a university hospital. We analyzed demographic variables, type of poison involved, suicidal or accidental nature of the poisoning, and the probability of admission, or death to the hospital. Results A total of 880 (6.1%) of the 14,300 poisonings treated in the same period occurred in people over 65 years of age. The most numerous group were individuals between 65-69 years-old (39%), followed by the group of 70-75 years-old (20%), being men 57%. In 88% of the cases a single poison participated, being by frequency alcohol (51.6%), drugs (29.5%), and household or industrial products (12.8%). Alcohol intoxication predominated in men up to 75 years of age, and above this age drug or suicidal intoxication predominated, mainly in women. A total of 145 (16%) subjects were hospitalized, the drugs most frequently implicated being digoxin and benzodiazepines. The probability of hospital admission was associated with intoxication by metformin, digoxin, lithium or with the age of the patient (OR per year = 1.03; 95% CI: 1.0-1.06). A total of 19 patients died (2.16%), mainly due to suicidal caustic ingestion (OR = 5.7: 95% CI: 1.4-23.6) or by drugs, directly related to metformin (OR = 10.1; 95% CI: 2.4-42.4). Conclusions The prevalence of poisoning in the elderly is not negligible, and physicians should have a high index of suspicion in a complex situation (AU)

Poisoning among the elderly.

OBJECTIVES: Poisonings continue to be an important public health problem. Herein, we analyzed the epidemiology of poisonings in elderly individuals. METHODS: Retrospective cohort study conducted between 2011 and 2019 in a university hospital. We analyzed demographic variables, type of poison involved, suicidal or accidental nature of the poisoning, and the probability of admission, or death to the hospital. RESULTS: A total of 880 (6.1%) of the 14,300 poisonings treated in the same period occurred in people over 65 years of age. The most numerous group were individuals between 65-69 years-old (39%), followed by the group of 70-75 years-old (20%), being men 57%. In 88% of the cases a single poison participated, being by frequency alcohol (51.6%), drugs (29.5%), and household or industrial products (12.8%). Alcohol intoxication predominated in men up to 75 years of age, and above this age drug or suicidal intoxication predominated, mainly in women. A total of 145 (16%) subjects were hospitalized, the drugs most frequently implicated being digoxin and benzodiazepines. The probability of hospital admission was associated with intoxication by metformin, digoxin, lithium or with the age of the patient (OR per year = 1.03; 95% CI: 1.0-1.06). A total of 19 patients died (2.16%), mainly due to suicidal caustic ingestion (OR = 5.7: 95% CI: 1.4-23.6) or by drugs, directly related to metformin (OR = 10.1; 95% CI: 2.4-42.4). CONCLUSIONS: The prevalence of poisoning in the elderly is not negligible, and physicians should have a high index of suspicion in a complex situation.

Poisoning among the elderly. / Intoxicaciones en la tercera edad.

OBJECTIVES: Poisonings continue to be an important public health problem. Herein, we analyzed the epidemiology of poisonings in elderly individuals. METHODS: Retrospective cohort study conducted between 2011 and 2019 in a university hospital. We analyzed demographic variables, type of poison involved, suicidal or accidental nature of the poisoning, and the probability of admission, or death to the hospital. RESULTS: A total of 880 (6.1%) of the 14,300 poisonings treated in the same period occurred in people over 65 years of age. The most numerous group were individuals between 65-69 years-old (39%), followed by the group of 70-75 years-old (20%), being men 57%. In 88% of the cases a single poison participated, being by frequency alcohol (51.6%), drugs (29.5%), and household or industrial products (12.8%). Alcohol intoxication predominated in men up to 75 years of age, and above this age drug or suicidal intoxication predominated, mainly in women. A total of 145 (16%) subjects were hospitalized, the drugs most frequently implicated being digoxin and benzodiazepines. The probability of hospital admission was associated with intoxication by metformin, digoxin, lithium or with the age of the patient (OR per year = 1.03; 95% CI: 1.0-1.06). A total of 19 patients died (2.16%), mainly due to suicidal caustic ingestion (OR = 5.7: 95% CI: 1.4-23.6) or by drugs, directly related to metformin (OR = 10.1; 95% CI: 2.4-42.4). CONCLUSIONS: The prevalence of poisoning in the elderly is not negligible, and physicians should have a high index of suspicion in a complex situation.

Encuesta a urgenciólogos sobre el papel del laboratorio en el manejo de las intoxicaciones agudas / Role of laboratory tests in managing acute poisonings: a survey of emergency physicians

Objetivo: Evaluar mediante una encuesta la percepción que los facultativos que atienden a pacientes intoxicados agudos tienen sobre el papel del laboratorio y conocer la importancia subjetiva que otorgan a determinadas pruebas para realizar el manejo clínico de las intoxicaciones agudas frecuentes. Método: La encuesta se dirigió a urgenciólogos que trabajan en servicios de urgencias(SU) de dos hospitales con Unidades de Toxicología Clínica (UTC) y médicos asistentes a cursos de formación toxicológica. Se solicitaba: datos profesionales, grado de importancia atribuida a las pruebas del laboratorio para las diferentes etapas asistenciales, un máximo de tres pruebas fundamentales para el cuidado de 17 intoxicaciones agudas e indicar una determinación de analítica básica y que no se realizase en su laboratorio. Resultados: Ochenta y ocho encuestas se consideraron válidas, de las cuales 69 (78%)se recogieron en cursos y 19 (22%) en 2 SU. La etapa asistencial a la cual los facultativos encuestados otorgan una mayor importancia al laboratorio es la etapa diagnóstica, independientemente del grupo al que pertenecen (62% si pertenecen a SU y 58% si asistieron a cursos). El papel del laboratorio es más relevante (p < 0,05) para aquellos médicos encuestados que trabajan en SU de los hospitales con UTC (52%) que para los (..) (AU)

Objective: To survey physicians who treat acute poisoning cases to determine their attitudes toward laboratory testing in these cases and also toward certain tests for the management of common poisonings. Methods: A questionnaire was sent to physicians working in the emergency departments of 2 hospitals with toxicology units and to physicians attending toxicology training courses. Survey items asked about professional data; the degree of importance the physicians attached to laboratory testing at different stages in the care process; which 3 tests the respondents considered important in 17 different acute poisoning scenarios; and which laboratory test they considered highly important was unavailable at the hospitals where the physicians worked. Results: Eighty-eight valid questionnaires were returned; 69 of them (78%) were from physicians attending toxicology courses and 19 (22%) were from emergency room physicians. The respondents in both groups believed that laboratory tests were most important when cases of acute poisoning were being diagnosed; 62% of the emergency department physicians and 58% of the trainee physicians expressed that opinion. More emergency department physicians at(..)(AU)

Valoración del riesgo de hepatotoxicidad en la intoxicación aguda por paracetamol cuando no es posible aplicar el nomograma de Rumack-Matthew / Assessing risk of liver toxicity in acute paracetamol intoxication when basing treatment on a Rumack-Matthew toxicity nomogram is not feasible

El nomograma de Rumack se utiliza para indicar el tratamiento antidótico con N-acetil-cisteína(NAC) en la intoxicación por paracetamol (PCT), pero tiene varias limitaciones de uso.La semivida de eliminación (t1/2) del PCT se incrementa a más de cuatro horas en caso de hepatotoxicidad. El objetivo de este trabajo es describir las características de los pacientes intoxicados por PCT de una serie en los que la aplicación del nomograma de Rumack nunca fuera posible y valorar su riesgo de hepatotoxicidad a través de la estimación de la t1/2.Se incluyeron los pacientes con una sobredosificación o intoxicación por PCT que acudieronal Hospital de Son Dureta de Palma de Mallorca y al Hospital Clínic de Barcelona durante un periodo de 5 años (julio 2005-julio 2010) en los que se dispusiera de al menos 2 determinaciones de PCT. La estimación de la t1/2 se realizó mediante un cociente entre dos determinaciones consecutivas separadas por un intervalo de tiempo de 2 o más horas. De 11 pacientes intoxicados por PCT a los que no se les pudo aplicar el nomograma de Rumack, tres desarrollaron hepatotoxicidad, dos de ellos fueron intoxicaciones accidentales producidas por ingesta fraccionada del fármaco y el tercero una intoxicación con intencionalidad suicida. En todos ellos la estimación del cálculo de la t1/2 puso de manifiesto que era superior a 4 horas. Proponemos que se complemente al nomograma de Rumack con la estimación de la t1/2 en los casos de intoxicación por PCT, y que esta estimación de la t1/2 sea la que aporte la información sobre la posible hepatotoxicidad de la intoxicación. Esto debe hacerse al menos en los casos en que existan dudas o se desconozca el tiempo transcurrido de la ingesta, o la misma haya sido fraccionada (AU)

The Rumack-Matthew nomogram is used to guide treatment with N-acetylcysteine (NAC) as an antidote for paracetamolintoxication, but this approach has limitations. The elimination half-life of paracetamol increases to over 4 hours in the presence of hepatic toxicity. The aim of this study is to describe the characteristics of a series of cases of paracetamol toxicity in which anomogram could not be used; the patient’s risk was assessed by means of the elimination half-life. Patients with paracetamolintoxication from a single or cumulative overdose who came to Hospital de Son Dureta de Palma de Mallorca and Hospital Clínic de Barcelona over a 5-year period (July 2005-July 2010) were included if the findings of at least 2 immunoas says for paracetamol concentration were available. Half-life was estimated by means of the ratio between 2 consecutive concentrations determined 2 hours apart. Of 11 patients with paracetamol intoxication for whom a Rumack-Matthew nomogram was not used, 3 had liver toxicity. Two of them were accidental intoxications caused by ingesting several doses of the drug. The third was an attempted suicide. In all cases, the elimination half-life exceeded 4 hours. We suggest that in cases of paracetamol intoxication the Rumack-Matthew nomogram be complemented by calculation of the elimination half-life, which will provide an indication of possible liver toxicity in these patients. This approach should be chosen at least when there are doubts about when paracetamol ingestion occurred or if intoxication is the result of several doses (AU)

Criterios AEFA sobre la Norma UNE-EN ISO 15189 / Criteria of AEFA on the Norm ISO 15189

La Norma 15189 ha significado un paso definitivo en el reconocimiento formal de la calidad en los laboratorios de análisis clínicos. La Asociación Española de Farmacéuticos Analistas entiende que es el documento de referencia obligada para cualquier tema relacionado con la calidad, ya que contiene requisitos aplicables al proceso analítico en su conjunto, así como a la gestión y a la competencia técnica del laboratorio. En el presente documento se presenta en una primera parte una introducción a la Norma y, en segundo lugar; los criterios que la Comisión de Certificación y Acreditación de AEFA tiene sobre diferentes aspectos de la misma, tanto en su aspecto formal como en sus requerimientos técnicos

The standard ISO 15189 has meant a definitive step in the formal recognition of the quality in the medical laboratories. AEFA understands that it is the document of referencet orced for any topic related to the quality, since it contains requeriments applicable to the analytical process in his ser, as well as to the management and to the technical competence of the medicallaboratory. In the present document one presents in the first part an introduction to the Norm and, secondly, the criteria that the Comisión de Certificación y Acreditación de AEFA has on different aspects ofthe same one, both in his formal aspect and in his technical requeriments